Southampton will assess the condition of Shane Long, who missed the win over Chelsea because of a knee injury.
Moussa Djenepo remains out with a hamstring injury but Kevin Danso has recovered from illness.
Patrick van Aanholt sustained another hamstring problem against Chelsea, adding to Palace’s injury crisis.
Christian Benteke missed that game with a muscle problem and joins Scott Dann, Gary Cahill, Joel Ward, Andros Townsend and Jeffrey Schlupp on the injury list.
The Saints are certainly turning their season around after the humiliating defeat by Leicester in October, taking 12 points from their past six fixtures.
I was at Selhurst Park for Match of the Day to see Jordan Ayew’s magnificent late Crystal Palace goal to defeat West Ham. Injuries are mounting up though, with Christian Benteke and Patrick van Aanholt the latest to be ruled out, so the Palace team almost picks itself for this match.
Danny Ings should return to the Southampton starting line-up for what could be a fascinating encounter.
Southampton manager Ralph Hasenhuttl: “You see the table is so close and we know we need to keep taking points.
“There’s still a long way to go, but I think in the first two months we played like a relegation team and now we play like a Premier League team.”
Crystal Palace manager Roy Hodgson: “We’ve got such a small squad and you can’t keep asking miracles of these players.
“If we can get through Christmas and if the chairman can give us four or five players to strengthen the squad, we’ll do extremely well. I’m hoping, new signings or not, this group of players will keep Crystal Palace in the Premier League.
“We’ve talked about needing signings for a long time so maybe this is the transfer window when that happens.”